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by Ursapharm


Eye drop

Chronic and seasonal allergic symptoms

3 months shelf life after opening

Without preservatives

Drop by drop design

Please store under 25ºc

Keep out of reach of children

Medication Usage


Understood, allergic reactions

What are the symptoms of an allergic reaction?

What are the symptoms of an allergic reaction?

When the cells in the body come into contact with foreign substances or potentially dangerous substances, the cells trigger defense mechanisms to protect themselves.

These foreign substances include allergens or pathogens. Allergens are mainly small proteins that, in general, do not pose a threat to the body.

However, individuals with sensitive constitutions have special antibodies in their bodies that cause the skin and mucous membranes to release various tissue hormones. The most crucial hormone in allergic reactions is histamine, which can trigger various bodily allergic reactions such as itching, redness, shortness of breath, or vasodilation.

In the eyelids and conjunctiva, there are many mast cells that contain histamine and mediators that cause inflammation.

Immune globulin E (IgE) molecules are present on the surface of mast cells. When the eyes are exposed to allergens in the external environment, several IgE molecules bind together, stimulating mast cells to release histamine and mediators, causing allergic reactions such as itching and redness in the eyes.

Mast cell stabilizers inhibit mast cells from degranulating, thereby suppressing histamine release by interrupting normal cell signaling.

When the body is first exposed to an allergen, the immune system is activated, and thereafter, each time the allergen is encountered again, this process repeats. In other words, when cells have an allergic reaction to a certain substance, they develop a memory for it. This means that if the body is exposed to this substance again, an allergic reaction will occur quickly – usually within a few minutes, but sometimes it may take up to an hour for the allergic reaction to appear.

Causes and Symptoms of Eye Sensitivity


Most eye sensitivity is related to pollen, but there are also many other factors that can irritate our conjunctiva, such as animal fur, dust mites, fungal spores, toxic insect venom, or certain food components. Individuals with sensitivities should identify their true allergens.

Eye allergies can be severe; the conjunctiva and mucous membranes immediately respond to foreign substances, causing vasodilation and the release of fluid, which manifests as watery eyes, runny nose, and redness of the eyes, commonly known as “allergic conjunctivitis.”

Common symptoms of allergies

Typical symptoms of allergic conjunctivitis include:

Allergic conjunctivitis is mainly divided into two types: acute and chronic


1.Acute allergic conjunctivitis:

This is usually caused by sudden exposure to a large amount of allergens such as pollen or pets, leading to an acute allergic reaction. In addition to itchy eyes, the conjunctiva and eyelids may also become swollen. Generally, the symptoms will alleviate on their own several hours later, and medication can help reduce the discomfort and shorten the duration of symptoms.

For more detailed information, please refer to the introduction page of Azelastin-Comod.

2.Chronic allergic conjunctivitis:

It is caused by chronic irritation from dust mites, mold, or contact lenses, resulting in symptoms such as itchy eyes, foreign body sensation, and conjunctival redness. In severe cases, the conjunctiva may also show inflammatory reactions such as papillary hypertrophy. The main treatment approach is to identify and avoid the allergens.

What is Soudium Cromoglicate?

Sodium Cromoglicate is a mast cell stabilizer used in the prevention and treatment of allergies.

It works by stabilizing the cell membranes, preventing the release of histamine from mast cells, and reducing allergic reactions. It also inhibits the release of inflammatory mediators from other inflammatory cells and reduces the sensitivity of peripheral sensory nerves.

“Allergo-Comod” is a preventive treatment product

” Allergo-Comod ” is generally used to treat

the following three types of allergic conjunctivitis:

Seasonal allergic conjunctivitis

Seasonal allergic conjunctivitis

Symptoms typically occur from early spring to late summer. It is more common in children, adolescents, and young adults, with a higher incidence in males than females. In addition to redness of the eyes, there may be cobblestone-like elevations on the tarsal conjunctiva visible when the upper eyelid is everted, as well as white dots in the limbal area. The cornea may have punctate epithelial erosions. This type of conjunctivitis is more common in children and adolescents, and allergic reactions usually gradually decrease after puberty.

Giant papillary conjunctivitis

Giant papillary conjunctivitis

It is characterized by the presence of giant papillae on the conjunctiva, mainly on the tarsal conjunctiva. The main symptoms include itching, increased sticky discharge, conjunctival congestion, and a sensation of a foreign body. Improper use of contact lenses, especially non-disposable soft contact lenses, is a common cause. Allergic reactions are triggered by the deposition of proteins and other substances on the contact lenses, leading to conjunctival swelling and the formation of giant papillae. Patients may experience discomfort, itching, increased discharge, and lens instability.



It refers to the inflammation of both the nasal and conjunctival mucosa, typically presenting symptoms such as sneezing and a runny nose. Eye allergy symptoms often occur simultaneously with nasal symptoms.

Why are preservative eye drops being replaced?

Preservative eye drops were commonly used to prolong their shelf life. Preservatives not only eliminate microorganisms but can also damage the normal ocular surface tissue.

Long-term use of eye drops containing preservatives can be toxic to ocular surface cells, including corneal epithelium and conjunctiva. It can lead to corneal epithelial cell death, corneal punctate ulcers, delayed corneal wound healing, conjunctivitis/conjunctival fibrosis, unstable tear film, dry eye symptoms, allergic reactions, eye discomfort, and more.

The higher the concentration of preservatives, the more pronounced these side effects can become.

Preservative eye drops:

Preservative eye drops:

Preservatives not only have the ability to eliminate microorganisms but also to a limited extent disrupt the cell connections between corneal epithelial cells. The purpose is to facilitate the penetration of medications into the cornea. While this can enhance the local effect of the medication, it also reduces corneal epithelial cell activity and cell adhesion. Preservatives can also disrupt the lipid layer of the tear film, making the eyes more prone to dryness and discomfort.

COMOD®-System patented bottle design

Friendly Reminder: Before using this product, please consult a specialist or professional healthcare provider if you are an infant, child, or pregnant woman.

COMOD®-System Intro Video

Symptoms Introduction

Data analysis