😚Reich Pharm:此網站必須啟用 ✪ Javascript ✪

01 / 03



by Ursapharm


Eye drop

Acute allergic symptoms

3 months shelf life after opening

Without preservatives

Drop by drop design

Please store under 25ºc

Keep out of reach of children

Medication Usage


Understood, allergic reactions

What are the symptoms of an allergic reaction?

What are the symptoms of an allergic reaction?

When the cells in the body come into contact with foreign substances or potentially dangerous substances, the cells trigger defense mechanisms to protect themselves.

These foreign substances include allergens or pathogens. Allergens are mainly small proteins that, in general, do not pose a threat to the body.

However, individuals with sensitive constitutions have special antibodies in their bodies that cause the skin and mucous membranes to release various tissue hormones. The most crucial hormone in allergic reactions is histamine, which can trigger various bodily allergic reactions such as itching, redness, shortness of breath, or vasodilation.

There are many mast cells in the eyelids and conjunctiva, which contain histamine and mediators that cause inflammation.

On the surface of mast cells, there are immunoglobulin E molecules (IgE). When the eyes are exposed to allergens from the external environment, several IgE molecules bind together, stimulating mast cells to release histamine and mediators, thereby causing allergic reactions in the eyes such as itching and redness.

Histamine antagonists (antihistamines)

Histamine antagonists (antihistamines)

is to block histamine H1 receptors, inhibiting the vasodilatory effect of histamine and reducing the degree of vasodilation caused by histamine.

When the body is exposed to an allergen for the first time, the immune system is activated. After that, each time the allergen is encountered again, this process repeats. In other words, when cells exhibit an allergic reaction to a substance, they develop a memory for it. This means that if the body is repeatedly exposed to this substance, an allergic reaction will quickly occur—usually within a few minutes, but sometimes it may take up to an hour for the allergic reaction to appear.

Causes and Symptoms of Eye Sensitivity


Most eye sensitivity is related to pollen, but there are also many other factors that can irritate our conjunctiva, such as animal fur, dust mites, fungal spores, toxic insect venom, or certain food components. Individuals with sensitivities should identify their true allergens.

Eye allergies can be severe; the conjunctiva and mucous membranes immediately respond to foreign substances, causing vasodilation and the release of fluid, which manifests as watery eyes, runny nose, and redness of the eyes, commonly known as “allergic conjunctivitis.”

Common symptoms of allergies

Typical symptoms of allergic conjunctivitis include:

Allergic conjunctivitis is mainly divided into two types: acute and chronic.


1.Acute allergic conjunctivitis:

It is usually caused by patients being exposed to a large amount of allergens, such as pollen or pet allergens, which leads to an acute allergic reaction. Besides itching, the conjunctiva and eyelids may also swell. Generally, the symptoms will resolve on their own after several hours, but medication can alleviate the discomfort and shorten the duration of symptoms.


2.Chronic allergic conjunctivitis:

It is caused by chronic irritations such as dust mites, mold, or contact lenses. This results in symptoms such as itching, foreign body sensation, conjunctival congestion, and, in severe cases, papillary hypertrophy. The treatment approach primarily focuses on identifying and avoiding the allergens.

For more details, please refer to the introduction page of Allergo-Comod.

What is Azelastine hydrochloride?

Azelastine is a second-generation H1 antihistamine ingredient. It does not pass through the blood-brain barrier, which means it does not have central nervous system side effects such as sedation or drowsiness. It is considered safe and has a longer duration of action compared to first-generation antihistamines.

Azelastine is classified as a long-acting anti-allergic compound and has strong selective blocking effects on H1 receptors. It can inhibit the synthesis and release of allergic reaction mediators, such as histamine.

“Azelastin-Comod” is generally used to treat the following two types of allergic conjunctivitis:


1.Easonal allergic conjunctivitis:

This is mainly caused by the abundant pollen and spores in the air during spring and summer when flowers, plants, and trees are in bloom. The symptoms are usually short-lived and mild. Some patients with allergic rhinitis may experience symptoms such as sneezing, runny nose, and wheezing.


2.Perennial allergic conjunctivitis:

This is usually caused by allergens that are present year-round in the environment, such as dust mites, pet dander (dog or cat hair), molds, and dust. The symptoms are similar to seasonal allergic conjunctivitis, occurring only in the conjunctiva and rarely affecting the cornea. Other allergic symptoms such as sneezing and runny nose often accompany it.

Why are preservative eye drops being replaced?

Preservative eye drops were commonly used to prolong their shelf life. Preservatives not only eliminate microorganisms but can also damage the normal ocular surface tissue.

Long-term use of eye drops containing preservatives can be toxic to ocular surface cells, including corneal epithelium and conjunctiva. It can lead to corneal epithelial cell death, corneal punctate ulcers, delayed corneal wound healing, conjunctivitis/conjunctival fibrosis, unstable tear film, dry eye symptoms, allergic reactions, eye discomfort, and more.

The higher the concentration of preservatives, the more pronounced these side effects can become.

Preservative eye drops:

Preservative eye drops:

Preservatives not only have the ability to eliminate microorganisms but also to a limited extent disrupt the cell connections between corneal epithelial cells. The purpose is to facilitate the penetration of medications into the cornea. While this can enhance the local effect of the medication, it also reduces corneal epithelial cell activity and cell adhesion. Preservatives can also disrupt the lipid layer of the tear film, making the eyes more prone to dryness and discomfort.

COMOD®-System patented bottle design

Friendly Reminder: Before using this product, please consult a specialist or professional healthcare provider if you are an infant, child, or pregnant woman.

COMOD®-System Intro Video

Symptoms Introduction

Data analysis