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Hysan Nasal Spray

German pharmaceutical technology has made significant advancements in improving the medication experience for every patient. One notable innovation is the development of preservative-free nasal sprays.



by Reichpharm

Hysan Nasal Spray, developed by Ursapharm, a German pharmaceutical company, features a unique bottle design known as the 3-K® system, providing you with a reassuring medication experience.

Nasal congestion is one of the symptoms derived from nasal allergies, but it is also the most troublesome one for patients. Nasal congestion can easily lead to insomnia and poor sleep, resulting in poor mental state the next day. If you want to relieve nasal congestion, what can you do that is quick and effective? Many people use nasal sprays for relief. Nasal sprays directly affect the blood vessels in the nasal mucosa, relieving nasal congestion by reducing nasal mucosal swelling. Nasal congestion is caused by the swelling of blood vessels inside the nasal cavity, and nasal sprays can directly act on the nasal mucosa, contracting it.

As we enter the transitional season, allergic diseases remain a common urban ailment among Hong Kong people. Most nasal allergy sufferers turn to pharmacies to purchase nasal sprays in order to relieve nasal congestion. It is worth noting that most nasal sprays contain a small amount of preservatives to prevent bacterial growth. However, traditional preservatives, while effective in eliminating microorganisms, can also damage the nasal mucosal lipid layer.

Hysan®Nasal Spray is a product developed by the German pharmaceutical company Ursapharm, designed with the patented 3-K® system. Even without preservatives, the formulation inside the bottle can prevent microbial growth and remain stable for up to 6 months. In the following, we will provide a detailed explanation of the technology and structure of the 3-K® system, as well as the ingredients and efficacy of Hysan Sea-Clear Nasal Spray.

Preservative-free nasal sprays are poised to become the cutting-edge of pharmaceutical application technology.

The currently popular nasal sprays are favored by the general public in Hong Kong for their ability to quickly and easily relieve nasal congestion by reducing nasal swelling. However, many of these products actually contain preservatives, such as Benzalkonium chloride. Despite being criticized for some time, these preservatives are still commonly used in nasal sprays due to their relatively low cost and effectiveness in maintaining the quality of the product.

The function of preservatives is to kill bacteria in the medication formulation, ensuring the microbial quality of the solution remains intact even after multiple doses from a multi-dose container. However, Benzalkonium chloride can cause allergic reactions such as swelling, redness, and itching. This is why consumers prefer to turn to preservative-free nasal sprays.

The emergence of the 3K® System has made patients realize that “adding preservatives” is just an excuse.

Hysan® Nasal Spray, which is free of any preservatives, utilizes the innovative 3K® System, a cutting-edge application system for dispensing liquid medication while ensuring permanent sterility of its contents. Therefore, the use of preservatives like Benzalkonium chloride is unnecessary. At the core of the 3K® System is the Non-Airless Pump, which effectively prevents contamination of the container’s contents.

Unveiling the Mystery of the 3K® System for You!

Nasal sprays can be classified into three categories, with “vasoconstrictors” being the most common ingredient.

Nasal sprays are commonly used medications for treating allergies, and besides being prescribed at clinics and hospitals, they are also available for purchase at pharmacies and drugstores. With a wide variety of nasal sprays available, it can be overwhelming to choose the most effective one. Selecting the right nasal spray is crucial as any slight negligence can lead to serious side effects. Therefore, before making a purchase, remember to consult with healthcare professionals or speak to a pharmacist at a nearby community pharmacy for guidance.

1. Vasoconstrictors

Common ingredients: Oxymetazoline/Xylometazoline
Also known as decongestants or sympathomimetic agents, vasoconstrictors are the most common type of nasal spray available in the market. Hysan® Sea-Clear Nasal Spray primarily contains Xylometazoline 1mg/ml as its main ingredient. Its main function is to constrict the blood vessels in the nasal mucosa, reducing swelling and improving nasal congestion. However, it does not have a therapeutic effect on other nasal symptoms such as sneezing or a runny nose.

Decongestant nasal sprays have a rapid onset of action, usually taking effect within a few minutes after use. They are suitable for situations where quick relief from nasal congestion is needed and are often used as a “rescue” treatment in clinical settings. Depending on the situation, they may be used in combination with steroid nasal sprays or antihistamines to improve allergic symptoms.
* It is recommended to avoid continuous use of decongestant nasal sprays for more than 7 days.

2. Steroid Nasal Sprays

Common ingredients: Fluticasone/Mometasone
Steroid nasal sprays are currently the mainstay treatment for allergic rhinitis and are prescription medications that require a doctor’s prescription to obtain.

Steroid nasal sprays are highly effective maintenance therapy for allergic rhinitis. They have better efficacy compared to oral antihistamines or antihistamine nasal sprays. Their main action is to suppress inflammation in the nasal mucosa, providing relief from symptoms such as nasal congestion, runny nose, sneezing, and also improving conjunctivitis.

Steroid medications have a slower onset of action, typically taking 6 to 12 hours for initial effectiveness. It may take several days of continuous use to achieve optimal efficacy. Therefore, they are often used long-term, which is the opposite of the characteristics of decongestant nasal sprays. If symptoms are controlled after using a steroid nasal spray, the doctor may recommend adjusting the dosage to the “lowest effective dose” to maintain the efficacy in controlling allergic rhinitis while minimizing the impact of side effects.
*These belong to prescription medications, please consult your healthcare professionals before purchasing them.

3. Antihistamine Nasal Sprays

Common ingredient: Azelastine
Antihistamine nasal sprays have a rapid onset of action, with effects often noticeable within 15 minutes. However, they may not provide as much relief for nasal congestion compared to steroid nasal sprays. They are effective in relieving symptoms such as a runny nose, sneezing, and itching.
* These products can cause drowsiness and fatigue, please consult your healthcare professionals before purchasing them.

“Eliminating preservatives” will become a new direction in the world of medical and pharmaceutical applications.

Consumers are increasingly concerned about the ingredients in products and are becoming more selective in their choices to prevent potential allergic risks. Therefore, nasal sprays without preservatives have a decisive competitive advantage. The 3K® System has made significant contributions to the safety and tolerability of nasal sprays. This innovative technology will continue to lead the future of nasal sprays not only in Europe but also worldwide.