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Dry Eye syndrome

HYLO® FRESH

by Ursapharm

MEDICATION INSTRUCTIONS

Eye drop

Dry eye severity

Sticky/foreign body sensation

Eyestrain

Long-term digital device use

6 months shelf life after opening

Without preservatives

Compatible with contact lens

Drop by drop design

Please store under 25ºc

Introduction
Medication Usage

HYLO® FRESH

HYLO® FRESH

HYLO® FRESH is used for the relief of irritated eyes. Irritated and dry eyes can result from environmental stress such as intensive computer-based activity, dry climate, draught, increased solar radiation, air pollution caused by dust or pollen or wearing contact lenses. For hundreds of years, preparations of eyebright (Euphrasia officinalis) are traditionally used for the treatment of conjunctival irritation with red and burning eyes, increased secretion of tears, swelling and redness of eyelids or eyelid margins.

Moreover, HYLO® FRESH contains sodium hyaluronate. Sodium hyaluronate increases the viscosity of the moisturizing solution and it becomes thicker than water. Thus, it stays longer on to the ocular surface.

Recommendation for someone with your needs

HYLO® FRESH Research findings on the eyeball

Research shows that among 65 patients with irritated eyes, daily use of eye drops containing Euphrasia officinalis (1-5 drops per eye) can effectively alleviate various eye problems caused by external irritants. The tested symptoms include conjunctival redness, swelling, discharge, burning sensation, and foreign body sensation. During the study, the symptoms of the patients’ left and right eyes were recorded on the 7th and 14th day, and compared with the symptom severity on the 1st day (baseline).

According to the above figure shows at baseline the right eye is affected in 53 patients, the left in 54 pa- tients. At the first follow-up examination after 7(±3) days, only 23 right and 22 left eyes are still affected. At the second follow-up after 14 (±3) days this symptom is only found in 3 eyes on each side.

According to the above figure shows at baseline, the right eye is affected in 11 patients, the left in 12 patients. At the first follow-up after 7(±3) days, only 1 eye on each side is still affected. At the second follow-up after 14(±3) days, no patients present with this symptom.

According to the above figure shows at baseline, the right eye is affected in 45 patients, the left eye in 46 patients. At the first follow-up after 7(±3) days, only 17 right and 15 left eyes are still affected. At the second fol- low-up after 14(±3) days, this symptom is only determined in 1 eye on each side.

According to the above figure shows at baseline, both eyes in 20 cases each are affected. At the first follow-up after 7(±3) days, only 3 eyes on each side are still affected. At the second follow-up after 14(±3) days, no patients present with this symptom.

According to the above figure shows at baseline, the right eye is affected in 13 patients, the left eye in 12. At the first follow-up after 7(±3) days, only 2 right and 3 left eyes are still affected. At the second follow-up after 14(±3) days, no patients present with this symptom.

According to the above figure shows, at baseline, both eyes are affected in 32 patients. At the first follow- up after 7(±3) days, only 6 right and 5 left eyes are still affected. At the second follow-up after 14(±3) days, this symptom is only determined in 1 right and 2 left eyes.

Hyaluronic Acid with an Extraordinary “Weight”

Hyaluronic acid is a natural component found in various organs and body fluids of the human body, such as tears. Due to its high binding capacity with water molecules, and its structural similarity to the glycoprotein molecules in the corneal mucous layer, hyaluronic acid exhibits excellent ocular binding abilities. When the eyes experience certain symptoms such as dryness or discomfort, it can provide the following benefits:

1.Moisturizes and hydrates, alleviating fatigue.

2.Improves the condition of the corneal epithelial cells.

3.Enhances the stability of the tear film.

HYLO® – Hyaluronic Acid

Distinguishes itself from other similar products on the market. It is synthesized through biotechnology, filtered, and purified. Only hyaluronic acid with “long molecular chains” and a molecular weight between 15,000 to 35,000 Daltons (Da) is selected. Due to its larger molecular weight and length compared to regular hyaluronic acid, it provides more effective and longer-lasting moisturizing and lubricating effects.

*For more information about “HYLO® -Hyaluronic Acid,” please click here to the “HYLO -GEL®” page.

High Medicinal Value of Euphrasia

Euphrasia has long been used as a medication for treating conjunctivitis and eyelid inflammation. Due to its vasoconstrictive and antibacterial properties, Euphrasia can alleviate inflammation, form a protective film on the surface of the eye, and provide effective relief for eye fatigue, irritations, and other eye disorders. It is also capable of alleviating excessive tear secretion and itching caused by colds and allergies.

Euphrasia can be widely used in patients of different ages

From infants to children, as research studies have confirmed its practicality and safety. A non-interventional study with anthroposophic eye drops containing Euphrasia on 121 children (aged 0-16 years) suffering from conjunctivitis (hyperemia, lid swelling, purulent secretion, sticky eyes, burning, itching, foreign body sensation). Most of the patients applied the eye drops 3 times a day. The duration of treatment was 10.4 days on average (±6.3 days). In 119 (= 98 %) cases all or almost all symptoms were cured after 5.2 (±4.1) days. In 2 patients no effect could be observed. In one patient additional treatment with an antibiotic was required. All doctors and almost (99 %) all parents assessed the tolerability of the eye drops as “very good”

Euphrasia-containing anthroposophic eye drops together with physiologic saline solution to 24 premature infants and newborns suffering from a blockade of efflux of tears. In most of the cases the treatment with antibiotics could be avoided. Therefore the authors recommended Euphrasia-containing eye drops additionally to physiologic saline solution in patients with red or tearing eye with white or yellowish secretion if these symptoms get worse within 48-72 hours. This pilot study confirms the excellent tolerance of Euphrasia-containing eye drops and their efficacy in alleviating unspecific symptoms of eye irritation.

Why are preservative eye drops being replaced ?

Preservative eye drops were commonly used to prolong their shelf life. Preservatives not only eliminate microorganisms but can also damage the normal ocular surface tissue. Long-term use of eye drops containing preservatives can be toxic to ocular surface cells, including corneal epithelium and conjunctiva. It can lead to corneal epithelial cell death, corneal punctate ulcers, delayed corneal wound healing, conjunctivitis/conjunctival fibrosis, unstable tear film, dry eye symptoms, allergic reactions, eye discomfort, and more. The higher the concentration of preservatives, the more pronounced these side effects can become.

Traditional preservative-containing eye drops

Traditional preservative-containing eye drops

Preservatives not only have the ability to eliminate microorganisms but also to a limited extent disrupt the cell connections between corneal epithelial cells. The purpose is to facilitate the penetration of medications into the cornea. While this can enhance the local effect of the medication, it also reduces corneal epithelial cell activity and cell adhesion. Preservatives can also disrupt the lipid layer of the tear film, making the eyes more prone to dryness and discomfort.

COMOD® system Patented bottle design

*Friendly Reminder: Before using this product, please consult a specialist or professional healthcare provider if you are an infant, child, or pregnant woman.

COMOD®-System Intro Video

Data analysis