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HYLO GEL®
by Ursapharm
MEDICATION INSTRUCTIONS
Eye drop
Dry eye severity++
Eyestrain
Burning sensation
Dry eye syndrome
Long-term digital device use
6 months shelf life after opening
Without preservatives
Compatible with contact lens
Drop by drop design
Please store under 25ºc
IntroductionMedication Usage
HYLO®-GEL
Understanding Dry Eyes Starts with the Tear Film
The tear film
is the outermost layer of the eye that constantly comes into contact with external irritants, helping to moisturize and protect the eyes.
The tear film consists of three layers,
each with its own unique functions
According to research reports, there are over 400 million dry eye syndrome patients worldwide, and the prevalence of dry eye syndrome continues to increase with age, with a sharp rise in patients around the age of 50. The causes of dry eye syndrome are commonly believed to be primarily associated with prolonged use of electronic devices, but in fact, there are numerous factors that can lead to dry eyes.
People at high risk for dry eye syndrome
People who stare at screens for a long time without enough blinking
People who wear contact lenses for a long time
Stay in a low humidity environment, such as: indoor places with air-conditioning or heating, or exposure to sunlight
Patients with immune system diseases, such as: arthritis, diabetes, thyroid disease
Long-term drug uses, such as: vasoconstrictors, antidepressants,sleeping pills, blood pressure medications
Women in Menopause (~over 45 years old)
Dry eye
Dry eye syndrome is not solely defined by insufficient tear secretion and can be broadly categorized into three types:
1.Aqueous-deficient type
This type occurs when the lacrimal glands degenerate, get damaged, or function abnormally, leading to reduced tear production.
2.Evaporative type
The meibomian glands, located at the base of the upper and lower eyelashes, are responsible for secreting oil and forming the lipid layer. A stable lipid layer helps reduce evaporation of the "aqueous layer." Insufficient secretion from the meibomian glands leads to continuous thinning of the lipid layer, resulting in rapid evaporation of the aqueous layer. This is often referred to as "meibomian gland dysfunction."
3.Mixed type
The majority of dry eye syndrome patients have a mixed type, which is characterized by a combination of the above two symptoms.
There are numerous methods to relief dry eyes, including artificial tears, light therapy, wearing specialized eyeglasses, and eye-protective nutrients, among others. Among these, the use of natural and preservative-free lubricating eye drops is the most common approach to relieving symptoms.
Sincerely recommend to those who experience the following issues
What is Hyaluronic Acid?
Hyaluronic Acid
is a highly effective moisturizing factor and a substance naturally produced in the human body. It is particularly abundant in the eyes and joints, where the liquid has the highest concentration of Hyaluronic Acid.
This hydrophilic molecule can hold a large amount of water and carry water that is 1000 times its own weight.Each blink forms a protective film for the eyes, providing long-lasting hydration, nourishment, and fatigue relief.
Due to the high binding capacity of hyaluronic acid with water and the high physical-chemical similarity with the glycoproteins of the corneal mucosal layer, it has an excellent ability to bond to the ocular surface, performing the following actions on the eye in case of suffering from Dry Eye:
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Hydration, moisturization, and fatigue relief
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Improvement of corneal epithelial cell condition
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Enhancement of tear film stability
Experience the difference with HYLO® Hyaluronic Acid!
From the above table, it can be seen that eye drops with higher concentrations of Hyaluronic Acid have weaker moisturizing abilities. The key factor affecting moisturizing ability is the size of the Hyaluronic Acid molecules.
Hyaluronic Acid brings you infinite possibilities
OCT= Optical Coherence Tomography (OCT) for retinal vasculature scanning;
TFT= Tear film thickness
Figure 1 : Thinning epithelium improves pressure dissipation more effectively compared to multi-layered normal epithelium, as any pressure is directly transmitted to the basal cell layer. However, this can potentially lead to side effects such as inflammation and pain.
Figure 2 : The diagram above illustrates the cellular motility and elasticity of normal epithelial tissue under pressure, as well as its response in the presence of normal extracellular matrix.
Figure 1 : The number of reepithelialized corneas in each treatment group 24 h post debridement.
FI= fluourescein;
HA= hyaluronic acid;
HPG= hydroxypropyl-guar;
Na= sodium
Figure 3 : Difference in the average area of reepithelialization 24 h post debridement across treatment groups when compared to HPG/HA. The mean difference in average reepithelialized area was calculated and presented by the number of pixels. The statistical difference in the area of reepithelialzation between HPG/HA group and HA-containing products was evaluated using a 1-way analysis of variance model. A P value of less than 0.05 was considered statistically significant. The table provided the average area and percenttage area of reepithelialization in each treatment group 24 h after debridement.
HA= hyaluronic acid;
HPG= hydroxypropyl guar;
SE= standard error
The figure above shows main signaling pathways activated in the cells by hyaluronic acid.
RHAMM= receptor for hyaluranon-mediated motility; CD44= antigen, a type 1 transmembranc receptor; Ras= protein; Src= kinase; p185HER2= tyrosine kinase p 185 human epidermal growth factor receptor 2
The figure above shows the changes of TEROS 40 before and after the application of various eye drops in dry eye patients (n= 10). The TEROS 40 increased 1 min after the application of all eye drops, but quickly decrased to original levels with artificaial tears or 0.05% sodium hyaluronate. In contrast, the 0.1% and 0.3% sodium hyaluronate drops maintained the higher level of TEROS 40 5 min after the application.
Arrow= time of instillation of eye drops;
TEROS 40 = tear evaporation rate at 40% ambient humidity
10 dry eye patients involved in this test.
Why are preservative eye drops being replaced?
Preservative eye drops were commonly used to prolong their shelf life. Preservatives not only eliminate microorganisms but can also damage the normal ocular surface tissue.
Long-term use of eye drops containing preservatives can be toxic to ocular surface cells, including corneal epithelium and conjunctiva. It can lead to corneal epithelial cell death, corneal punctate ulcers, delayed corneal wound healing, conjunctivitis/conjunctival fibrosis, unstable tear film, dry eye symptoms, allergic reactions, eye discomfort, and more.
The higher the concentration of preservatives, the more pronounced these side effects can become.
Preservative eye drops:
Preservatives not only have the ability to eliminate microorganisms but also to a limited extent disrupt the cell connections between corneal epithelial cells. The purpose is to facilitate the penetration of medications into the cornea. While this can enhance the local effect of the medication, it also reduces corneal epithelial cell activity and cell adhesion. Preservatives can also disrupt the lipid layer of the tear film, making the eyes more prone to dryness and discomfort.
COMOD®-System patented bottle design
Friendly Reminder: Before using this product, please consult a specialist or professional healthcare provider if you are an infant, child, or pregnant woman.
