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Dry Eye syndrome

HYLO INTENSE®

by Ursapharm

MEDICATION INSTRUCTIONS

Eye drop

Dry eye severity+++

Wound healing of tear lipid film

Eyestrain

Long-term digital device use

Post-operative care

6 months shelf life after opening

Without preservatives

Drop by drop design

Please store under 25ºc

Consult your specialist before use

Introduction
Medication Usage

HYLO INTENSE®

Understanding Dry Eyes Starts with the Tear Film

HYLO INTENSE® able to simultaneously address discomfort from three types of stratification.

The tear film

Is the outermost layer of the eye that constantly comes into contact with external irritants, helping to moisturize and protect the eyes. The tear film consists of three layers, each with its own unique functions

The tear film is composed of three layers

According to research reports, there are over 400 million dry eye syndrome patients worldwide, and the prevalence of dry eye syndrome continues to increase with age, with a sharp rise in patients around the age of 50. The causes of dry eye syndrome are commonly believed to be primarily associated with prolonged use of electronic devices, but in fact, there are numerous factors that can lead to dry eyes.

Individuals at high risk for dry eyes

People who stare at screens for a long time without enough blinking

People who wear contact lenses for a long time

Stay in a low humidity environment, such as: indoor places with air-conditioning or heating, or exposure to sunlight

Patients with immune system diseases, such as: arthritis, diabetes, thyroid disease

Long-term drug uses, such as: vasoconstrictors, antidepressants,sleeping pills, blood pressure medications

Women in Menopause (~over 45 years old)

HYLO INTENSE®

can simultaneously relief discomfort associated with three types of tear film instability :

Aqueous-deficient type：

This type occurs when the lacrimal glands degenerate, get damaged, or function abnormally, leading to reduced tear production.

Evaporative type :

The meibomian glands, located at the base of the upper and lower eyelashes, are responsible for secreting oil and forming the lipid layer. A stable lipid layer helps reduce evaporation of the "aqueous layer." Insufficient secretion from the meibomian glands leads to continuous thinning of the lipid layer, resulting in rapid evaporation of the aqueous layer. This is often referred to as "meibomian gland dysfunction."

Mixed type:

The majority of dry eye syndrome patients have a mixed type, which is characterized by a combination of the above two symptoms.

*Sincerely recommend to those who experience the following issues :

*There are numerous methods to relief dry eyes, including artificial tears, light therapy, wearing specialized eyeglasses, and eye-protective nutrients, among others. Among these, the use of natural and preservative-free lubricating eye drops is the most common approach to relieving symptoms.

01 What is Hyaluronic Acid ?

Hyaluronic Acid is a highly effective moisturizing factor and a substance naturally produced in the human body. It is particularly abundant in the eyes and joints, where the liquid has the highest concentration of Hyaluronic Acid. This hydrophilic molecule can hold a large amount of water and carry water that is 1000 times its own weight. Each blink forms a protective film for the eyes, providing long-lasting hydration,

nourishment, and fatigue relief. Due to the high binding capacity of hyaluronic acid with water and the high physical-chemical similarity with the glycoproteins of the corneal mucosal layer, it has an excellent ability to bond to the ocular surface, performing the following actions on the eye in case of suffering from Dry Eye :

1. Hydration, moisturization, and fatigue relie

2.Improvement of corneal epithelial cell condition

3.Enhancement of tear film stability

For more information about “HYLO®-Hyaluronic Acid,” please click here to the “HYLO-GEL®” page.

02 Multi-functional cell-level patented repair particle Ectoine®

A: Protein-bound water molecules: There are relatively few water molecules on the surface of proteins.

B: Protein in “Ectoine® – water molecule” solution: The formation of “Ectoine® Hydro Complex” increases the number of water molecules, enhancing hydrophobic interactions and thus improving protein stability.

A: Without ectoine® : external stress factors (like UV irradiation) cause membrane damage, water loss and release of stress mediators, which act as second messengers for infiammatoryreactions.

B: With ectoine® : the Ectoine® Hydro Complex protects the membrane against external stress factors ; stress mediator releasse is prevented.

A: Lipid bilayer in water: The bilayer is stabilized by hydrophilic interactions within the inner region.

B: Lipid bilayer in “Ectoine® ” water solution: The presence of “Ectoine® Hydro Complex” leads to increased interactions between the head groups and water, resulting in enhanced fluidity of the cell membrane.

According to the definition of dry eye syndrome by the Dry Eye Work Shop (DEWS 2007), “the etiology of dry eye syndrome is associated with increased tear film osmolarity and ocular surface inflammation.”

“High osmolarity of tears” (easy loss of moisture) is a contributing factor in patients with insufficient tear secretion and abnormalities in the composition of tear film, leading to rapid tear evaporation. This factor is particularly evident in patients with a combination of tear film abnormalities, resulting in significant symptoms. This creates a vicious cycle of tear film instability and excessive evaporation, leading to a sustained increase in tear film osmolarity and further ocular surface inflammation, thereby promoting tear film instability.

According to picture 3 :

1.Ectoine® in HYLO INTENSE® acts as a protective solute that safeguards the epithelial cells of the cornea and conjunctiva from damage caused by increased osmotic pressure in tears. Its unique feature is to protect cells from osmotic stress without affecting cell metabolism or the functionality of cellular proteins.

2.Ectoine® forms a protective shell around the eye, improving the binding between the ocular surface and water molecules. Additionally, “HYLO® Hyaluronic Acid” effectively binds water molecules, restoring the normal osmotic pressure of the tear film. Ectoine® protects protein molecules in the cell membrane of epithelial cells from denaturation.

3.Ectoine® and “HYLO® Hyaluronic Acid” provide protection to the epithelial cells of the cornea and conjunctiva, thereby inhibiting the release of inflammatory mediators triggered by external stress factors.

Illustration of high-concentration Ectoine® molecules interacting with the tear film lipid layer.

4.Ectoine® improves the arrangement of lipid molecules in the tear film. It allows the lipid molecules secreted by the meibomian glands to redistribute on the surface of the lipid layer, causing them to aggregate and increasing the fluidity of the hydrophobic molecular platform. Hyaluronic acid, similar to the glycoprotein structure in the mucin layer, enhances the stability of the water and mucin layers, preserving more moisture.

5.Ectoine® increases the compressibility of the lipid layer. With each blink, the lipid layer is compressed and then stretched again. The lipid layer needs to have a “fully reversible” characteristic to restore a stable arrangement on the tear film surface. Ectoine® enhances the elasticity of the lipid layer and promotes the even diffusion of lipid molecules across the tear film surface. Improving the distribution of the lipid layer reduces excessive tear evaporation.

In summary, all three factors of dry eye syndrome :

high osmolarity of tears, ocular inflammation, and unstable tear film, are positively influenced by HYLO INTENSE® .

Why are preservative eye drops being replaced?

Preservative eye drops were commonly used to prolong their shelf life. Preservatives not only eliminate microorganisms but can also damage the normal ocular surface tissue. Long-term use of eye drops containing preservatives can be toxic to ocular surface cells, including corneal epithelium and conjunctiva. It can lead to corneal epithelial cell death, corneal punctate ulcers, delayed corneal wound healing, conjunctivitis/conjunctival fibrosis, unstable tear film, dry eye symptoms, allergic reactions, eye discomfort, and more. The higher the concentration of preservatives, the more pronounced these side effects can become.

Traditional preservative-containing eye drops

Preservatives not only have the ability to eliminate microorganisms but also to a limited extent disrupt the cell connections between corneal epithelial cells. The purpose is to facilitate the penetration of medications into the cornea. While this can enhance the local effect of the medication, it also reduces corneal epithelial cell activity and cell adhesion. Preservatives can also disrupt the lipid layer of the tear film, making the eyes more prone to dryness and discomfort.

COMOD® system patented bottle design

*Friendly Reminder: Before using this product, please consult a specialist or professional healthcare provider if you are an infant, child, or pregnant woman.